Damage from Chemotherapy:
Induced Peripheral Neuropathy (CIPN)
What is CIPN?
drugs are toxic chemicals (poisons) that attack fast growing cells
(rapidly dividing cells). The
theory behind using these toxins is that it will
destroy the fast growing cancer cells before it does
too much damage to normal cells.
Hair is a quickly
growing cell and this is the reason that hair loss is a common
side effect of chemotherapy.
Bone marrow produces
fast growing cells. Normally, when blood cells wear
out in the body, they are replaced by new ones from
the bone marrow. When the chemotherapy drugs
damage these fast growing cells, it can cause a low blood count,
which can result in other side
effects such as fatigue, headaches, and chills.
It is sometimes even necessary to do a blood
from chemotherapy drugs
Chemotherapy is hardest on the nervous system due
to the fact that nerve cells are more sensitive than
The nervous system transmits
information between the central nervous system (brain
and spinal cord) and the rest of the body. It is
designed to transmit feeling such as touch and
temperature. It delivers messages from
sight; it delivers messages to the muscles to get them
cells are more sensitive to these toxins then other
cells, they are often affected
and can be damaged easily. This may also
be the reason for cognitive problems following
chemotherapy, also known as "chemo
fog" or "chemo-brain".
exposure to the chemotherapy drugs, the cells that
responsible for producing myelin, the fatty substance
that helps insulate and protect nerve conducting
fibers, can become damaged.
changes in chemotherapy patients can develop months or
years after treatment. The
onset of these symptoms are variable. Some drugs
may cause symptoms during or immediately after the
first dose, and some have a delayed onset of symptoms,
up to several weeks, months, or even years after the
severity of these symptoms is related to the
cumulative dosage of the drug received.
someone with pre-existing neuropathy (no matter what the
cause) may be at risk for more severe and long lasting
Symptoms of Post
Loss of feeling in
the hands and feet can make it hard to pick up small
objects and cause clumsiness and difficulty walking.
Some people with nerve damage first notice a
"pins and needles" feeling, not unlike when
an arm or leg "falls asleep". Foot nerve damage after chemo is very
common which results in stabbing pain and numbness.
As motor nerves are
the most sensitive to toxins, this nerve damage
may make you feel clumsy and cause difficulty in daily
activities such as opening jars, fastening buttons, or
even squeezing toothpaste tubes. Loss of
balance and coordination is also due to this
Per the American Cancer Society,
"Chemo-induced peripheral neuropathy (CIPN) is caused by the
chemotherapy drugs used in cancer treatment."
(Neuropathy is also sometimes called paraesthesia or
"The symptoms or signs of CIPN depend mostly on
which nerves are involved. The most common symptoms
tingling (or a "pins and needles"
trouble with tripping and stumbling while
loss of feeling (numbness)
decreased or no reflexes
increased sensitivity to temperature (usually
cold) or pressure, so that things hurt more than
trouble passing urine
blood pressure changes
"CIPN often affects both sides of the body the
same way; for example, the toes of both feet. It can
cause severe pain and can affect your ability to do
everyday things like walk, write, button your shirt,
or pick up a coin. If it gets very bad it can cause
very serious problems like changes in your heart rate,
trouble breathing, paralysis, or organ failure"
This is the reason that medical doctors have to
keep close watch over their patients when receiving
these long-term side effects of chemotherapy?
When a person develops neuropathy due to
chemotherapy, the oncologist will prescribe drugs to
cover up the symptoms and the patient will get a
pamphlet entitled “Living with Neuropathy”. There is
hope that it will get better after the chemo is
quite often, the damaged cell will continue to
deteriorate and the symptoms will get worse. The only
way to correctly manage this chronic neuropathy is to
address the real causes, not the symptoms.
the Nerve Damage be Reversed?
the myelin sheathing of the nerve cells are damaged or
they degenerate due to the cancer treatment, the signals
being transmitted are scrambled, resulting in your body
receiving signals that real interpreted as heat, cold, tingling, pain, etc.
is similar to an electrical wire that is covered with
insulation, and the insulation is beginning to crumble.
Without insulation, the unprotected wire will start
the signals don't go through the nerve and thus you get numbness
in sensory nerves and clumsiness, lack of coordination
and muscle weakness when a motor nerve is damaged.
The muscles aren't getting the signals they need to
doctors are beginning to be aware that that increased
levels of Thiamine (Vitamin B1) in the blood stream are
effective in reducing and reversing nerve damage.
Unfortunately, the oral intake of vitamin B1 does not
greatly increase the levels of B1 in the blood stream.
reason for this is that Thiamine), like all of the B vitamins, is water-soluble.
Thiamine cannot be stored in the body and flushes out
within 4 to 5 hours.
chemotherapy induced peripheral neuropathy has been
found to be made worse by insufficient amounts of B12 in
B12 supports the sheathing that protects nerve cells and
has shown in studies to promote the regeneration and
growth of nerve cells.
the past, it has been difficult to remedy the B12
reason for this is that while vitamin B12 is readily
stored by the body, it is not readily absorbed by
the body. For this reason much larger amounts have been
used in supplementation, but even large oral dosages
have not been an adequate solution.
reading. There is a solution.
Remedy for this Problem:
might have heard of the new type of vitamin B1 being
produced, called Benfotiamine. It is a fat-soluble
version of vitamin B1. What does this mean? It
means this new form of vitamin B1 can be taken orally in
large dosages and it will not flush out of the body the
way ordinary Thiamine (vitamin B1) does.This is due to the fact that this type of B1 will
be delivered into the blood stream where it can travel
to the cells and be used.
available is Methylcobalamine (called Methyl B12). This
is the form of vitamin B12 that can be directly utilized
by the body.When
regular B12 is taken, the body has to convert it into
the Methyl B12 in the gut.This type of B12 already comes in the
can I find these supplements?
where we have researched products and found one that we
found will work and reverse the damage)
vitamins talked about above are available together.
It was formulated 8 years and and found to be
the right combination of B vitamins to give the body all
the tools it needs to repair the nerves.
It was developed by a biochemist who had neuropathy and
needed it to work.
name of the product is WSN®
Nerve Support Formula” It
contains both Benfotiamine and Methyl B12. The result is
that the blood stream levels of vitamin B1 and vitamin
B12 can be greatly increased, providing the nutritional
support needed by the body to rapidly and far more
effectively to decrease or eliminate the symptoms of neuropathy
by repairing the nerve damage that was done.
“Nerve Support Formula”
is far more effective than either the Benfotiamine or
Methyl B12 alone due to the combination of these two vital B
vitamins, The formula also
includes other B vitamins and D3 that work together to
help the body to utilize these two important vitamins.
Benfotiamine and Methyl B12 have been shown to be
non-toxic and without any side effects even in very high
vitamins have a 90-Day money back guarantee and the
company who makes it also has a live support line.
This money back guarantee means that you can buy 1, 2 or
3 bottles (up to three months worth) and return them if
this doesn't work for you. The company has product
consultants that will guide you through whatever
you need to do to get relief. They don't just sell
you a vitamin.
It costs $44.20 for 120 capsules. It will
not interfere with any medications you might be taking.
The Nerve Support
Formula is made at an "FDA Inspected
Facility" and cGMP labs (Good Manufacturing Practice
Facility).This means it
adheres to Good Manufacturing Practices for supplement manufacturers. This process guarantees the potency, purity and quality
this product. Made in the USA.
Go to Quality
of WSN Manufacturing
Sounds too good to be true. They have a very high
success rate with lots of
Chemotherapy – “I realized I was having a difficult
time remembering things, plus the pain, tingling, and
numbness in my feet and legs were getting worse, not
better. Three months after taking the Nerve Support
Formula, the condition was about 90% improved, with not
only the painful symptoms reversing, but the bonus was
more energy and clearer thinking”Linda
We have used our best judgment in compiling this information. The Food and Drug Administration may not have evaluated the information presented. Any reference to a specific product is for your information only and is not intended to diagnose, treat, cure, or prevent any disease