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The Safety of
Linus Pauling Institute found that adverse effects
have only been documented from Vitamin B6 supplements
and never from food sources.
safety concerning only the supplemental form of
vitamin B6 (pyridoxine, also called pyridoxine
hydrochloride) is discussed here.
vitamin B6 is a water-soluble vitamin and is excreted
in the urine, long-term supplementation with very
high doses of pyridoxine (Vitamin B6) may result
in painful neurological symptoms known as sensory
include pain and numbness of the extremities and in
severe cases, difficulty walking. Sensory neuropathy
typically develops at doses of pyridoxine (Vitamin B6)
in excess of 1,000 mg a day.
there have been a few case reports of individuals who
developed sensory neuropathies at doses 500 mg of
Vitamin B6 daily over a period of months.
of the studies in which a neurological examination was
performed reported evidence of sensory nerve damage at
intakes below 200 mg of pyridoxine (Vitamin B6) daily.
prevent sensory neuropathy in virtually all
individuals, the Food and Nutrition Board of the
Institute of Medicine set the tolerable upper intake
level for pyridoxine (Vitamin B6) at 100 mg/day for
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